Dracula vs Van Helsing is an asymmetrical game for two players.
Van Helsing's objective is to eliminate all of Dracula's life points, while Dracula's objective is to turn the 4 inhabitants of the same district into vampires.
The game is played over a maximum of five rounds, each round ending when the players have resolved all five districts. Each player has 5 cards, one for each district. The cards have a value and an ability.
Each turn, they draw a card and may discard it or exchange it with one of their 5 cards. When a card is discarded, its ability (such as revealing cards or swapping cards) is applied.
The players then resolve each district by comparing the value of the two cards in each district to determine the winner.
The winner transforms a human token into a vampire or removes one life point from Dracula.
The game ends immediately if Dracula loses his life points or turns all 4 inhabitants of a district into vampires.
Otherwise, the player who achieves his objective wins the game after the 5 rounds.